References

  1. American Thyroid Association. Hypothyroidism: A Booklet for Patients and Their Families.https://www.thyroid.org/wp-content/uploads/patients/brochures/Hypothyroidism_web_booklet.pdf. Accessed March 27, 2019.
  2. ATA/AACE Taskforce on Hypothyroidism in Adults. Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocrine Pract. 2012;18(6):988-1028.
  3. Tirosint [package insert]. Lugano, Switzerand: Institut Biochimique SA (IBSA); 2018.
  4. Ernst FR, Sandulli W, Elmor R, Welstead J, Sterman AB, Lavan MK. Retrospective study of patients switched from tablet formulations to a gel cap formulation of levothyroxine: results of the CONTROL Switch Study. Drugs in R&D. 2017;17:103-115.
  5. Ruchala M, Szczepanek-Parulska E, Zybek A. The influence of lactose intolerance and other gastro-intestinal tract disorders on L-thyroxine absorption. Polish J Endocrinology. 2012;63(4):318-323.
  6. McMillan M, Rotenberg KS, Vora K, et al. Comorbidities, concomitant medications, and diet as factors affecting levothyroxine therapy; results of the CONTROL Surveillance Project. Drugs in R&D. 2015;16(1):53-68.
  7. Data on file, Institut Biochimique SA (IBSA).
  8. Synthroid [package insert]. North Chicago, IL: AbbVie Inc; 2018.
  9. Pabla D, Akhlanghi F, Hossein Z. A comparative pH-dissolution profile study of selected commercial levothyroxine products using inductively coupled plasma mass spectrometry. Eur J Pharm Biopharm. 2009;72:105-110.
  10. Seng Yue S, Benvenga S, Scarsi C, Loprete L, Ducharme MP. When bioequivalence in healthy volunteers may not translate to bioequivalence in patients: differential effects of increased gastric pH on the pharmacokinetics of levothyroxine capsules and tablets. J Pharm Pharm Sci. 2015;18(5):844-855.
  11. Kennedy J. Herb and supplement use in the US adult population. Clin Ther. 2005;27(11):1847-1858.
  12. Tirosint-SOL [package insert]. Lugano, Switzerland: Institut Biochimique SA (IBSA); 2018.
  13. US Department of Health and Human Services/Food and Drug Administration. Approved Drug Products with Therapeutic Equivalence Evaluations. 39th ed. https://www.fda.gov/media/71474/download Accessed May 22, 2019.
  14. Based on RelayHealth eVoucherRx™ Network pharmacy paid claims from April 2018–March 2019.